His approach to clinically applied anthropology places patient perspectives and anthropological methods within clinical care. It considers how emergency departments can respond to social determinants of health by developing new care pathways and incorporating anthropologists into clinical teams.

His clinical and scholarly work has included syndemic interventions that address interacting health and social problems; anticoagulant reversal and bleeding pathways; care for patients with sickle cell disease; HIV and hepatitis C screening and linkage; harm reduction; and treatment and follow-up for opioid and other substance use disorders. His current research also includes remote blood pressure monitoring and pharmacist-led telehealth after emergency department discharge, mobile and telemedicine buprenorphine, and clinical diagnostic biomarkers.

Dr. Wilson contributes to emergency department operations and patient flow at Tampa General Hospital while continuing to practice clinical emergency medicine. During the COVID-19 pandemic, he participated in hospital and community response efforts and provided public education through television, radio, and online media.

His research and academic work have received support from public and industry sources. He has presented at international, national, state, and regional conferences and has authored peer-reviewed articles, book chapters, and Clinical Anthropology 2.0: Improving Medical Education and Patient Experience, co-authored with Roberta D. Baer.

Dr. Wilson coordinated emergency medicine coverage of local NFL games from 2015 to 2023 and served as a team emergency medicine physician for the Tampa Bay Lightning from 2014 to 2023. He also serves on academic and community boards, conducts peer review for medical journals, and teaches and mentors residents, medical students, premedical students, and anthropology students.